In this study, a high throughput, 3D microfluidic platform (Nephroscreen) was assessed for the detection of drug-induced kidney injury in pharmaceutical development. The system was established with four model nephrotoxic drugs (cisplatin, tenofovir, tobramycin and cyclosporin A) and tested with eight pharmaceutical compounds. Measured parameters included cell viability, release of lactate dehydrogenase and N-acetyl-β-D-glucosaminidase, barrier integrity, release of specific miRNAs, and gene expression of toxicity markers. Drug-transporter interactions were also determined. The results showed the potential of the Nephroscreen for robust detection of nephrotoxicity and drug-transporter interactions.
Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies
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