Adoptive cell therapy (ACT), based on the infusion of expanded autologous tumor-infiltrating lymphocytes (TIL), has demonstrated durable complete tumor regressions in metastatic melanoma. However, results for renal cell carcinoma (RCC) have been dismal as far as now. In the present study, the researchers have characterized the presence and activity of T cells using autologous tumor cell lines from RCC patients and compared them to ones generated from metastatic melanoma patients. TILs from primary RCC specimens could be isolated from the patients, expanded ex vivo, and could recognize tumors cell lines in vitro. T-cell responses were detected in the majority of RCCs analyzed. Extensive in vitro characterization of TILs revealed a unique functional pattern, with weaker responses compared with metastatic melanoma. These findings have relevance for the development of ACT for patients with RCC.
T-cell responses in the microenvironment of primary renal cell carcinoma—implications for adoptive cell therapy
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