Non Animal Testing Database

Characterization of immune response in renal carcinoma tumors from patients

Copenhagen University Hospital, Herlev, Denmark
Adoptive cell therapy (ACT), based on the infusion of expanded autologous tumor-infiltrating lymphocytes (TIL), has demonstrated durable complete tumor regressions in metastatic melanoma. However, results for renal cell carcinoma (RCC) have been dismal as far as now. In the present study, the researchers have characterized the presence and activity of T cells using autologous tumor cell lines from RCC patients and compared them to ones generated from metastatic melanoma patients. TILs from primary RCC specimens could be isolated from the patients, expanded ex vivo, and could recognize tumors cell lines in vitro. T-cell responses were detected in the majority of RCCs analyzed. Extensive in vitro characterization of TILs revealed a unique functional pattern, with weaker responses compared with metastatic melanoma. These findings have relevance for the development of ACT for patients with RCC.
T-cell responses in the microenvironment of primary renal cell carcinoma—implications for adoptive cell therapy
Marco Donia, Inge Marie Svane
Added on: 09-14-2021
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!