In colorectal cancer, the degree of infiltration of T lymphocytes has been associated with a favourable prognosis. MicroRNAs are small non-coding RNAs that epigenetically regulate diverse biological and pathologic processes, including immune response and tumor progression. The let-7 microRNA family has been shown to play an important role in host immunity. In the present study, the researchers examined let-7 miRNA expression in colorectal cancer tissues from two U.S.-nationwide prospective cohort studies. This analysis was correlated with imaging analysis of immune cell infiltration of the tumors. The study shows that a specific microRNA of the let-7 family is associated with suppressing antitumor immunity in colorectal cancer and suggests that it could be a potential target of immunotherapy.
MicroRNA let-7, T cells, and patient survival in colorectal cancer
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