Non Animal Testing Database

Characterization of immunosuppressive features in cervical cancer patients' tumors

October 2014
VU University Medical Center, Amsterdam, Netherlands
Cervical cancer is the fourth leading cause of cancer-related death among women worldwide and is caused by sexually transmitted human papillomavirus. Cervical cancer tumor cells are able to escape the immune system by provoking an immunosuppressive state of their microenvironment. In the present study, the researchers studied immune-cell subsets present in tumors from patients by flow cytometry and characterized the profiles of cytokines released by the cells. The data reveals that the immunosuppressive microenvironment in patients with cervical cancer is due to the accumulation of immunosuppressive immune effector cells and elevated levels of cytokine IL10. This study should inform the future development of immunotherapeutic interventions aimed at breaking microenvironmental immune suppression in cervical cancer.
High and interrelated rates of PD-L1þCD14þ antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical cancer
Tanja D. de Gruijl
Added on: 09-14-2021
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