Head and neck squamous cell carcinoma (HNSCC) affects 600,000 new patients worldwide each year. The recent discovery of highly immunogenic and tumor-specific antigens called cancer-testis antigens (CTA) has opened new doors for specific tumor-targeted treatments using passive or active immunotherapeutic strategies. In this study, the researchers have used an in silico approach to select a subset of CTAs to be evaluated for expression in tissues from 89 HNSCC patients. Three CTAs were found in the vast majority of the tumors and also were associated with a poor outcome while another one was associated with disease-free survival. The study shows that the identification of human tumor antigens is important not only for the analysis of antitumor immune responses and the development of immunotherapies but also for the identification of molecular markers useful for diagnosis or prognosis.
A comprehensive expression analysis of cancer testis antigens in head and neck squamous cell carcinoma revels MAGEA3/6 as a marker for recurrence
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