Non Animal Testing Database

New biomarkers for rare type of lymphoma identified in patients material

McGill University Health Centre, Montréal, Canada
Cutaneous T-cell Lymphoma (CTCL) is a rare type of cancer in which pathogenesis remains only partially understood. Identification of novel diagnostic markers and future therapeutic targets are essential. In the present study, the researchers have tested the expression of cancer-testis genes (CT) in a cohort of CTCL patients, normal skin samples, skin from benign inflammatory dermatoses and patient-derived CTCL cells. The study shows that a number of CT genes are specifically expressed in CTCL patients and can be used as biomarkers or novel targets for immunotherapy.
Ectopic expression of cancer testis antigens in cutaneous T-cell lymphoma (CTCL) patients
Denis Sasseville, Ivan V. Litvinov
Added on: 09-14-2021
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