Non Animal Testing Database

P-selectin dynamics in Alzheimer's disease

The Vrinnevi Hospital, Norrköping, Sweden
Alzheimer's disease is a multifactor disorder that can induce alterations in different tissues. Recently, more attention is being driven to other areas apart from the central nervous system, such as the cardiovascular system. A lot of knowledge is being generated on this topic, but little is still known about the role of platelets in Alzheimer's disease. In this study, the aim was to investigate P-selectin, which co-localizes with amyloid precursor proteins and is found in endothelial cells, in Alzheimer's disease. P-selectin and surface-bound P-selectin were analyzed in circulating blood samples of moderate Alzheimer's patients. The results show that soluble P-selecting was found to be increased in Alzheimer's samples and surface-bound P-selectin was decreased upon in vitro agonist stimulation. In conclusion, the researchers show that Alzheimer's disease seems to influence the levels of circulating P-selectin and also platelet reactivity, opening the door to further research on this topic to explore and understand the consequences of Alzheimer's disease.
P-selectin paradox and dementia of the Alzheimer type: circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised
Petter Järemo
Added on: 08-30-2021
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