Detection and determination of different amyloid-beta peptides are critical for the proper development of diagnostic tools for Alzheimer's disease. Despite the big advances in the last years, it is still difficult to detect the onset and pathological evolution of the disease without relying on cognitive tests. Here, two polymers are tested to be used in glass microchips to reliably separate several amyloid-beta peptides detected by fluorescence. The results show that the polymers had different adsorptions of amyloid-beta. The polymer having the lowest adsorption was further validated in the glass microchips as linear and the limit of detection was found to be around 200nM. The system coated with this polymer allowed for the proper resolving of the different amyloid-beta peptides and it could be applied to the detection of these peptides in human cerebrospinal fluid samples. Thus, in this study, the researchers propose a new system that can evolve into a promising clinical application to detect different amyloid-beta peptides and their concentrations to establish them as biomarkers of onset and progression of the disease.
Neutral polymers as coatings for high resolution electrophoretic separation of Aβ peptides on glass microchips
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