Clinical diagnosis of Parkinson's and Alzheimer's disease is difficult at early stages with a high risk of mixed diagnosis. Therefore, there is a need to develop tools that can reliably differentiate these diseases, as it is extremely important to start the disease-specific treatment as early as possible. Here, a microRNA profiling method is developed to analyse the exosomal microRNAs isolated from the cerebrospinal fluid of patients with Parkinson's and Alzheimer's disease. The researchers found several microRNAs differentially expressed in Parkinson's exosomes in the cerebrospinal fluid from both healthy controls and Alzheimer's patients. Afterwards, a computational method was used to analyse the enriched pathways in the Parkinson's microRNA profiles. Moreover, they found that there were other types of RNA that were also differentially expressed in exosomes of cerebrospinal fluid in Parkinson's disease and Alzheimer's disease patients. Altogether, these data support the idea of using exosomal RNA from the cerebrospinal fluid as a reliable biomarker sensitive enough to make a differential diagnosis of Parkinson's disease.
Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease
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