The brain is the organ that has the highest oxygen consumption in the body, making it more prone to undergo oxidative stress after any dysregulation. Therefore, oxidative stress is observed in many neurodegenerative diseases, and it is thought that the oxidation of individual proteins can be disease-specific. In Alzheimer's disease, it has been observed that peptidyl-prolyl isomerase is sensitive to oxidation. Here, human post-mortem hippocampus samples of Alzheimer's patients are analysed with a newly developed ELISA assay to detect and quantify oxidised peptidyl-prolyl isomerase. The researchers found that their new method successfully measured the oxidised protein present in lysates of the patients' hippocampus and that it was possible to observe a rise in the oxidised ratio in early Alzheimer's. Overall, this study presents evidence of a new tool that could easily detect a new potential biomarker of Alzheimer's disease. In the near future, this technique should be tested with other fluids to further develop its possibilities.
A multifunctional ELISA to measure oxidised proteins: oxPin1 in Alzheimer's brain as an example
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