Alzheimer's disease progression affects several cell types in the body. It has been reported in vitro that amyloid-beta can bind and disrupt red blood cells. Peripheral red blood cells of Alzheimer's disease patients were analyzed to find out their potential interactions with amyloid-beta. It was found that the presence of elongated red blood cells was significantly higher in Alzheimer's patients and that the major part of the red blood cells in these samples was amyloid binding-positive. Furthermore, these interactions seemed to induce different morphologies. The results of this study support the further exploration of the potential of red blood cells morphology as an easily accessible feature to use as a biomarker for Alzheimer's disease.
The peripheral blood of Aβ binding RBC as a biomarker for diagnosis of Alzheimer's disease
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