Non Animal Testing Database

Plasma from dementia patients affects endothelial cells negatively

Università Politecnica delle Marche, Ancona, Italy
In the last years, there is growing evidence that Alzheimer's disease might include vascular dysfunction. Endothelial cells have been suggested to be disrupted early in the development of Alzheimer's disease and this has been related to disturbed vascular homeostasis. Here, the plasma from patients with mild cognitive impairment or Alzheimer's disease was used to treat cultured human aortic endothelial cells. The results showed an impaired regulation of several parameters related to endothelial function in both groups of patients, but more pronounced in plasma coming from Alzheimer's patients. This study confirms that the plasma of demented patients can affect endothelial function negatively, emphasizing the urgency of investigating therapeutic approaches aimed at protecting the endothelium in early stages of dementia.
Effects of plasma from patients affected by mild cognitive impairment and Alzheimer's disease on cultured endothelial cells
Eleonora Salvolini
Added on: 08-22-2021
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