Alzheimer's disease is one of the most prevalent neurodegenerative disorders. Ageing is a major factor in the development of spontaneous Alzheimer's disease and is characterized by a progressive deterioration of brain homeostasis and function. Here, the role of the G-protein coupled receptor CXCR4 in ageing and Alzheimer's disease is investigated, since a reduction in its levels is present in Alzheimer's disease and it has been linked to developmental processes and synaptic plasticity. The results show that CXCR4 is necessary for cell proliferation and its knock-down induces cytotoxicity in human neural cells. Also, a potential signalling pathway is described, through which CXCR4 activation may work. Overall, this study suggests CXCR4 as a potential novel target to study ageing and Alzheimer's disease and offers mechanistic insights into its regulatory functions, which could lead to new approaches in therapeutic strategies.
Reducing CXCR4 resulted in impairing proliferation and promoting aging
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