Non Animal Testing Database

Scaffold properties condition breast cancer cell activity

October 2016
IEIIT Institute, Genoa, Italy
Described is the development of a hydrogel scaffold to use 3D culture to model human breast cancer. Due to the culture in 3D conditions, a human breast cancer cell line shows properties that resemble better the in vivo conditions compared to 2D cultures. Also, the researchers found that there is a direct correlation between the elasticity of the hydrogels and proliferation and cluster formation, showing that cancer studies need more realistic models.
Microenvironment complexity and matrix stiffness regulate breast cancer cell activity in a 3D in vitro model
Silvia Scaglione
Added on: 07-12-2021
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