Non Animal Testing Database
EnglischDeutsch

Patient-derived leukemia model reveals a key oncogene in severe congenital neutropenia

2021
University Hospital Tuebingen, Tuebingen, Germany
Severe congenital neutropenia (CN) is a pre-leukemic bone marrow failure syndrome that can evolve to acute myeloid leukemia (AML). Certain genetic mutations are frequently observed in CN patients, although how they drive the transition from CN to AML (CN/AML) is unclear. In this study, the researchers established an in vitro model of leukemia evolution in CN using patient-derived iPSCs and CRISPR-Cas9-mediated introduction of gene mutations. Using this model, they described the upregulation of the gene BAALC as a key leukemogenic event and identified a small-molecule targeting CN/AML blasts without affecting healthy cells. This strategy could be applied to treat CN/AML or some de novo AML patients.
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia
Julia Skokowa
#564
Added on: 05-11-2021
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!