Non Animal Testing Database

SARS-CoV-2 elevates its own protein production

Ludwig‐Maximilians‐University Munich, Munich, Germany(1)
University of Lübeck, Lübeck, Germany(2)
The pathogenicity of SARS-CoV-1 and SARS‐CoV‐2 are higher compared to other coronavirus family members. The reason has already been revealed by the identification of the so-called SARS‐unique domain (SUD). It encodes a protein that binds to the cell's ribosomes to enhance translation of the coronavirus proteins, but not of the host proteins. A deeper understanding of the pathogenic virus is essential to identify possible drug targets. By screening the human proteome with the help of yeast-2-hybrid screen interaction, a human cell line and crystal structure analysis, the stimulating components of the host translation machinery could be identified.
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation
Albrecht von Brunn(1), Rolf Hilgenfeld(2)
Added on: 05-05-2021
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