Non Animal Testing Database

Ligand selection strategy improves drug discovery targeting viruses

December 2020
University of Vienna, Vienna, Austria
Virus-specific proteases are essential for the cellular virus replication and are thus the focus for drug discovery strategies. Using a ligand selection strategy, chemical electrophilic probes were identified that target highly specifically the active site of these enzymes. Thus, even in live-cell models and complex cell samples, these probes can be used to detect proteases like the two SARS-CoV-2 proteases analysed in this study. Screening for identification of customized inhibitors is another application of this method. These drugs are more likely to be effective when used to treat infections. The method is suitable for high-throughput screening and for discovering inhibitors for a wide range of target proteins also beyond coronavirus proteases. A patent has been filed for the method.
A ligand selection strategy identifies chemical probes targeting the proteases of SARS‐CoV‐2
Thomas Böttcher
Added on: 01-29-2021
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!