Patient-specific COVID-19 characteristics and drugs
2021
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
In order to dissect COVID-19-driven immune host responses, the authors performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analysed the data using a combination of conventional and data-driven co-expression analysis. Additionally, publicly available data was used to show the distinction from COVID-19 to other diseases. Further, stratified transcriptomes predicted patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host.
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Thomas Ulas
Added on: 01-29-2021
[1] https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00823-5[2] https://www.bionity.com/en/news/1169490/covid-19-has-multiple-faces.html
