Non Animal Testing Database

Protective effects of azithroymcin on ventilator-induced lung injury

University of Iceland, Reykjavík, Iceland
The study analysed the effect of Azithromycin pre-treatment of human bronchial and alveolar-derived cell lines on mechanical stress in a cyclical pressure air-liquid interface device (CPAD). That model is used to demonstrate the disruption of the epithelial barrier with the increased inflammatory response in lung tissue associated with ventilator-induced lung injury (VILI). The findings from this study confirm the usefulness of the CPAD to model ventilator-induced lung injury and suggest that Azithromycin has barrier protective and immunomodulatory effects, attenuating the inflammatory response during mechanical stress and might therefore be lung protective during mechanical ventilation. The model could be used to assess further drug candidates that influence barrier integrity and modulate the inflammatory response.
Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injury
Sigurbergur Karason
Added on: 12-23-2020
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