Non Animal Testing Database

Predicting the toxicity of nanoparticles for safer industrial materials

November 2020
Jožef Stefan Institute, Ljubljana, Slovenia
The prediction of diseases associated with nanomaterials is currently hampered by an incomplete understanding of the underlying mechanisms. As part of the EU project "SmartNanoTox", it has now been found that for special materials, the long-term inflammatory response of the lung to a single nanoparticle exposure can be attributed to two previously unknown key cellular events. First, a new quarantine process, i.e. the deposition of excreted particles enveloped by biological molecules on the cell surface; second, the so-called nanomaterial cycle, which conditions the uptake and excretion of nanoparticles between different alveolar lung cell types. With the help of a few in vitro measurement data in combination with in silico modelling, the scientists were able to predict the acute or chronic toxicity of nanoparticles and thus the course of inflammatory reactions in the lung for 15 different materials.
Prediction of chronic inflammation for inhaled particles: the impact of material cycling and quarantining in the lung epithelium
Janez Štrancar, Hana Kokot
Added on: 12-14-2020
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!