This study investigated the developmental neurotoxicity (DNT) induced by chemical mixtures compared to single chemicals. The neurotoxicity was tested on human-induced pluripotent stem cells (hiPSC) that were differentiated into mixed cultures of neurons and astrocytes. Single chemicals showed no toxicity, whereas mixtures of different chemical classes had DNT effects when working in a similar mode of action.
The results show an increased number of neurons and brain-derived neurotrophic factor (BDNF) protein levels, impairment of neurite outgrowth and synaptogenesis. These effects represent autism-like cellular changes. Infants and children are generally co-exposed to mixtures in the environment underscoring the need to implicate this condition in test assays.
Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept
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