Non Animal Testing Database

Blood-brain barrier chips enable disease modeling

The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, USA(1)
The Department of Physiology and Cell Biology and the Regenerative Medicine and Stem Cell (RMSC) Res, Be`er Sheva, Israel(2)
This iPSC-derived blood-brain barrier chip exhibits physiologically relevant transendothelial electrical resistance and accurately predicted blood-to-brain permeability of pharmacologics. Chips created from individuals with neurological diseases predicted disease-specific lack of transporters and disruption of barrier integrity.
Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications
Clive N. Svendsen(1), Gad D. Vatine(2)
Added on: 05-06-2020
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