Non Animal Testing Database

ToxCast ER Pathway Model for endocrine disruptors

validierte Methode
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The ToxCast estrogen receptor (ER) pathway model is a mathematical model that combines the results from 18 high-throughput screening (HTS) assays from the ToxCast and Tox21 research programs. The HTS assays measure ER binding, dimerization, chromatin binding, transcriptional activation and ER-dependent cell proliferation. The model uses activity patterns across the in vitro assays to predict whether a chemical is an ER agonist or antagonist, or is otherwise influencing the assays through a manner dependent on the physics and chemistry of the technology platform (“assay interference”). The output of the model provides an area under the curve (AUC) value for the potential of a chemical to cause ER agonism, normalized with respect to the positive control chemical, estradiol. Validated and regulatory accepted under TM2016-08 (US) by EURL ECVAM (TSAR list).
The ToxCast Estrogen Receptor Agonist Pathway Model
Added on: 07-03-2020
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