Non Animal Testing Database

Carcinogenicity assay

validierte Methode
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The In-vitro-CTA using the BALB/c 3T3 cell line is aimed at detecting the carcinogenic potential of chemicals. The assay is based on the phenotype change of cells undergoing the first steps of the conversion from normal cells to cell foci with oncogenic properties. In vitro CTAs such as the BALB/c 3T3 CTA have been shown to recapitulate a multistage process that closely models some stages of in vivo carcinogenesis. Validated under TM2004-07 (EU) by EURL ECVAM (TSAR list), regulatory acceptance is ongoing.
In vitro BALB/c 3T3 Cell Transformation Assay
Added on: 07-03-2020
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