Non Animal Testing Database
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Peptide assay for detection of sensitizing chemicals

validierte Methode
2009
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The DPRA supports the discrimination between sensitizing and non-sensitizing chemicals. It measures in chemico the binding of test chemicals to model synthetic peptides. In skin proteins, many amino acids contain electron-rich groups capable of reacting with sensitizers. Therefore, these peptides are used by the assay so they can react with electrophilic chemicals (skin sensitizers). Validated and regulatory approved under TM2009-06 (EU) by EURL ECVAM (TSAR list), OECD Test No. 442C.
Direct Peptide Reactivity Assay
EURL ECVAM
#221
Added on: 07-03-2020
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