Non Animal Testing Database

Skin sensitisation determination by CD86-marker

validierte Methode
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The U-SENS test detects whether a chemical has a sensitizing or non-sensitizing effect on the skin. This test is based on the flow cytometry measurement of a protein marker produced by U937 cells exposed to test chemicals. This reaction is one of the reactions of a key event of the Adverse Outcome Pathway (AOP), which is related to skin sensitization. Validated and regulatory approved under TM2013-02 (EU) by EURL ECVAM (TSAR list), OECD Test No. 442E.
U-SENS™ - Myeloid U937 Skin Sensitisation Test
Added on: 07-03-2020
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