Non Animal Testing Database

Epidermis model for testing skin irritation

validierte Methode
European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy
The Modified EpiDerm SIT is an in vitro method that has been developed and optimized to predict the skin irritation potential of a chemical. The method utilizes a commercially available three-dimensional tissue construct EpiDermTM (EPI-200) produced by MatTek Corporation (US). The test consists of a topical exposure of the substance to a human reconstituted epidermis model. Cell viability is measured by the formation of a blue formazan salt that is quantitatively measured after extraction from tissues. Validated and regulatory accepted under TM2008-01 (EU) by EURL ECVAM (TSAR list), OECD Test No. 439.
Modified EpiDerm Skin Irritation Test for Hazard Identification and Labelling of Chemicals According to EU Classification System
Added on: 07-02-2020
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