AxoSim's BrainSim platform is an in vitro model that, when combined with an AI, enables improved toxicology and drug screening of the central nervous system. For this purpose, three-dimensional spheroids are cultivated based on inductive, pluripotent stem cells. These are then used in the BrainSim platform, where further differentiation generates three relevant, critical cell types (neurons, astrocytes and oligodendrocytes) of the central nervous system in a biomimetic environment. The cultivation method induces a high level of myelination and reflects important properties of the characteristic cells of the CNS and their interaction, and allows for an imaging of the brain structure. Reactions between the different cell types are characterized using electrophysiology, immunohistochemistry (ICC), histology, flow cytometry and gene expression. These can be accompanied by phenotypic changes in the mechanisms of action of the drugs to be tested. As a result, relevant predictive data is determined more quickly than is possible with the previous, established methods. The BrainSim platform thus enables the identification of neurotoxic substances and improves drug development and research into neurodegenerative diseases.
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