Non Animal Testing Database

BrainSim: 3D in vitro model for drug and toxicology screening of the central nervous system

AxoSim, Inc., New Orleans, USA
AxoSim's BrainSim platform is an in vitro model that, when combined with an AI, enables improved toxicology and drug screening of the central nervous system. For this purpose, three-dimensional spheroids are cultivated based on inductive, pluripotent stem cells. These are then used in the BrainSim platform, where further differentiation generates three relevant, critical cell types (neurons, astrocytes and oligodendrocytes) of the central nervous system in a biomimetic environment. The cultivation method induces a high level of myelination and reflects important properties of the characteristic cells of the CNS and their interaction, and allows for an imaging of the brain structure. Reactions between the different cell types are characterized using electrophysiology, immunohistochemistry (ICC), histology, flow cytometry and gene expression. These can be accompanied by phenotypic changes in the mechanisms of action of the drugs to be tested. As a result, relevant predictive data is determined more quickly than is possible with the previous, established methods. The BrainSim platform thus enables the identification of neurotoxic substances and improves drug development and research into neurodegenerative diseases.

AxoSim [1]   URL
Added on: 06-06-2023
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!