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Spatial organelle networks in mesenchymal stem cells

2023
Georgia Institute of Technology and Emory University, Atlanta, USA
Mesenchymal stem cells are multipotent cells that have been explored as a therapeutic method for treating a variety of diseases. Studying how organelles are structured in these cells can answer questions about their characteristics and potential. Herein, rapid multiplexed immunofluorescence was performed to understand the spatial organization of 10 organelle proteins and the interactions between them in the bone marrow and umbilical cord mesenchymal stem cells (MSCs). Spatial correlations, colocalization, clustering, statistical tests, texture, and morphological analyses were conducted at the single cell level, shedding light onto the interrelations between the organelles and comparisons of the two MSC subtypes. This data-driven single-cell approach provided by rapid subcellular proteomic imaging enables personalized stem cell therapeutics.
Spatial subcellular organelle networks in single cells
Ahmet F. Coskun
#1823
Added on: 06-05-2023
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