Non Animal Testing Database

Obesity treatment restores natural killer cell metabolism in patients

Maynooth University, County Kildare, Ireland
People with obesity (PWO) have functionally defective natural killer (NK) cells, with a decreased capacity to produce cytokines and kill target cells, underpinned by defective cellular metabolism. It is plausible that the changes in peripheral NK cell activity are contributing to the multimorbidity in PWO, which includes an increased risk of cancer. This study investigated whether a 6-month therapy with long-acting glucagon-like peptide-1 (GLP-1) analogues, which are an effective treatment for obesity, could restore NK cell functionality in a cohort of 20 PWO. The data demonstrated that PWO who received GLP-1 therapy have improved NK cell function and cell cytokine production, and that the reported improvements appear to be independent of weight loss.
Glucagon-like peptide-1 therapy in people with obesity restores natural killer cell metabolism and effector function
Andrew E. Hogan
Added on: 06-05-2023
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