Non Animal Testing Database

Organoids for rare liver cancer research

Royal Netherlands Academy of Arts and Sciences, Utrecht, Netherlands(1)
The Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands(2)
Fibrolamellar carcinoma (FLC) represents a rare type of childhood liver cancer. The aim of this study was to gain molecular understanding of FLC tumorigenesis by using CRISPR-engineered human hepatocyte organoids. In the developed human hepatocyte organoid models different FLC and FLC-like genetic alterations were introduced to reflect the genetic backgrounds of different cases of FLC. Phenotypic characterizations and comparisons with primary FLC patient tumor samples revealed mutant organoid-tumor similarities. Thus, the engineered human organoid models facilitate the study of FLC.
Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss
Delilah Hendriks(1), Benedetta Artegiani(2)
Added on: 05-08-2023
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