Non Animal Testing Database

Digital spatial profiling of pancreatic cancer

Duke University, Durham, USA
The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction of pancreatic ductal adenocarcinoma (PDAC) risk. The researchers used digital spatial RNA profiling of dysplastic epithelium from surgically resected IPMN tissues from 12 patients to differentiate subtypes and predict genes associated with malignancy. Gene expression patterns were compared between pancreaticobiliary, intestinal, and gastric foveolar epithelium tumours. This study delineates markers of high-risk IPMN and insights into malignant progression.
Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification
Peter J. Allen
Added on: 05-02-2023
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