Non Animal Testing Database

Senescence in aged human neurons associated with Alzheimer’s disease

December 2022
The Salk Institute for Biological Studies, La Jolla, USA(1)
University of California, La Jolla, USA(2)
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is associated with tissue dysfunction and an increased risk of age-related disease. The researchers found that Alzheimer’s disease (AD) brains have significantly higher proportions of neurons that express senescence markers, and their distribution indicates bystander effects. AD patient-derived directly induced neurons (iNs) exhibit strong transcriptomic, epigenetic, and molecular biomarker signatures, indicating a specific human neuronal senescence-like state. Finally, the researchers show that targeting senescence-like neurons with senotherapeutics could be a strategy for preventing or treating AD.
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease
Fred H. Gage(1), Jerome Mertens(1), Joseph R. Herdy(2)
Added on: 12-16-2022
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