The aim of this study was to enable imaging of endothelial cell behaviour under physiological conditions, with a focus on chronic fibrotic pathologies within the liver.
Therefore, a fluorescent reporter was developed that allows the monitoring of the endothelial-to-mesenchymal transition of cells during fibrotic liver disease. Liver cells were cultivated in an organ-on-a-chip system and the developed reporter allowed high-resolution single-cell tracking by live cell microscopy.
It was shown that liver-on-a-chip (LOAC) platforms provide a flexible, optically accessible, and physiologically relevant microenvironment to study the vascular dynamics of endothelial-to-mesenchymal transition during liver disease. This will help to increase the understanding of how vascular plasticity and dysfunction affect local tissue environments such as within the liver.
Novel application of live imaging to determine the functional cell biology of endothelial‑to‑mesenchymal transition (EndMT) within a liver‑on‑a‑chip platform
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