Non Animal Testing Database

Commercial dishwashers destroying the gut

December 2022
University of Zurich, Davos, Switzerland
Experiments using advanced cell cultures, organoids and gut-on-a-chip technology revealed that residues from rinse agents damage the protective layer in the gut. This can contribute to the onset of chronic diseases such as allergies, diabetes or multiple sclerosis. Various biomolecular methods were applied to analyze the effect that commercial detergents and rinse aids have on intestinal cells. These substances were diluted reflecting the amounts that would be present on dry dishes. High doses of rinse agents killed the intestinal epithelial cells and lower doses increased permeability. Also, the activation of several genes and cell signalling proteins was observed, which could trigger inflammatory responses. The rinse agent component alcohol ethoxylates was identified to be mainly responsible for the toxic effects on the gastrointestinal tract.
Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
Cezmi A. Akdis
Added on: 12-02-2022
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