Non Animal Testing Database

Rebooting the immune system in MS therapy

November 2022
University and University Hospital Zurich, Zurich, Switzerland
Autologous hematopoietic stem cell transplantation (aHSCT) is a highly effective treatment of multiple sclerosis (MS), as it depletes autoreactive cells and subsequently renews adaptive immune cells. This study investigates the T cell depletion during aHSCT and the T cell renewal after aHSCT in MS. Therefore, the dynamics of new and surviving T cells was examined in 27 patients after aHSCT. Moreover, 12 healthy persons and 16 patients with untreated MS were included in the study. Lymphocytes of the participants were investigated by multidimensional flow cytometry, T cell receptor sequencing, specificity testing, and human leukocyte antigen (HLA) genotyping over a period of 2 years. The data showed substantial survival of autoreactive CD4+ T cells early after transplantation but a complete renewal of the T cell repertoire later. In addition, the authors performed a complete characterization of the renewed T cell population. The results will provide a valuable resource for understanding the mechanisms mediating the efficacy of aHSCT in patients with MS.
Dynamics of T cell repertoire renewal following autologous hematopoietic stem cell transplantation in multiple sclerosis
Roland Martin
Added on: 11-15-2022
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