Non Animal Testing Database

Investigation of the role of dopamine in rheumatoid arthritis in peripheral blood

IfADo-Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
This study investigates the possible involvement of the neurotransmitter dopamine in rheumatoid arthritis (RA). Therefore, in particular, the function of the dopaminergic pathway in peripheral immune cells of RA patients was investigated and the mode of action of dopamine on B cell function was further elucidated. Patients with a confirmed diagnosis of RA as well as healthy controls and two cohorts of patients with other chronic inflammatory rheumatic diseases were recruited. Peripheral blood was collected and peripheral blood mononuclear cells (PBMCs) were isolated and further investigated. Expression of dopamine receptors (DRs) was investigated by flow cytometry, in-vitro stimulation of receptors was performed and effects on B cell activation were assessed. Dopamine content in PBMCs and D1DR expression on B cells was found to be significantly higher in RA females and expression of the receptor D1DR correlated positively with disease duration and severity only in women. These results indicate sex-specific differences in the dopaminergic pathway in RA, with a proinflammatory feature of the D1DR pathway in women, thus suggesting this pathway as a new therapeutic target for future treatment approaches in RA women.
Dopamine receptor 1 expressing B cells exert a proinflammatory role in female patients with rheumatoid arthritis
Silvia Capellino
Added on: 11-03-2022
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