Non Animal Testing Database

Neuronal organoids mimicking network activity of fetal brain

Georg-August-University, Goettingen, Germany
In this study, the directed self-organization of human induced pluripotent stem cells towards a highly interconnected neuronal network is reported. The described bioengineered neuronal organoids (BENOs) consist of functionally integrated excitatory and inhibitory neurons as well as supporting glia. Giant depolarizing potential (GDP)-like events observed in early BENO cultures mimic early network activity of the fetal brain. The observed reduction of GDPs in > 40-day BENOs indicates progressive neuronal network maturation. Collectively, BENOs demonstrate neuronal network function classically found in the developing brain, such as GDP, and within the more matured human brain, such as neuronal plasticity. The similarity of structural and functional properties to the fetal brain may allow for the application of BENOs in studies of neuronal plasticity and modelling of diseases as well as in drug development.
Developmental GABA polarity switch and neuronal plasticity in bioengineered neuronal organoids
Wolfram-Hubertus Zimmermann, Maria-Patapia Zafeiriou
Added on: 08-24-2022
Back to Top
English German
Lush Prize Winner 2022Lush Prize Winner 2022
Winner of the Animal Protection Prize of Lower Saxony 2022Winner of the Animal Protection Prize of Lower Saxony 2022

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!