Non Animal Testing Database

Neuronal model of the sensation of mechanical stimuli

Hannover Medical School, Hannover, Germany
Within this study, a robust differentiation protocol for the generation of certain human somatosensory mechanoreceptor-like neurons (termed SZ-LTMRs), from induced pluripotent stem cells (iPSCs)-derived neuronal precursor cells is described. The SZ-LTMRs express functional mechano-transducers Piezo1 and Piezo2, corresponding to the in vivo situation. They are also able to convert mechanical stimuli into electrical signals and have specialized axon termini. The iPSC-derived cells can be used as a model of sensory nerve endings, and provide an in vitro model to study the role of Piezo1 and Piezo2 in mechanosensation. The model is expected to be useful to study human mechanotransduction.
Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2
Shuyong Zhu, Abel Viejo-Borbolla
Added on: 08-18-2022
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