Non Animal Testing Database

Antimicrobial mechanisms of neutrophils against biofilms of the oral cavity

December 2020
Hannover Medical School, Hannover, Germany(1)
University of Veterinary Medicine Hannover, Hannover, Germany(2)
This study aims to investigate the antimicrobial mechanisms of neutrophils against different biofilms of the oral cavity. Therefore, the capacity of commensal (Streptococcus oralis) and pathogenic (Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans) monospecies biofilms to induce or inhibit selected antimicrobial mechanisms of human neutrophils was investigated. In particular, the formation of bacterial species-specific neutrophil extracellular traps, the production of reactive oxygen species, and the secretion of matrix metalloproteinases was studied. The findings may provide new opportunities for future strategies for the treatment of oral cavity diseases.
Neutrophils exhibit an individual response to different oral bacterial biofilms
Carina Mikolai(1), Maren von Köckritz-Blickwede(2)
Added on: 08-08-2022
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