Non Animal Testing Database

Bacterial nanocellulose as novel carrier for intestinal epithelial cells

December 2019
University Hospital Wuerzburg, Wuerzburg, Germany
Nowadays, biopolymers such as bacterial nanocellulose (BNC) represent interesting scaffold materials for innovative tissue engineering concepts, as they can be produced in a faster and standardized process flow without the need for animal material. In this study, BNC was presented as a suitable support for the development of Caco-2-based in vitro models of human intestine. The BNC-based models exhibited organ-specific properties that included typical cellular morphologies, characteristic protein expression profiles, representative ultrastructural features, and the formation of a dense epithelial barrier. The demonstration of in vivo-like transport activities confirmed the high quality of the BNC-based Caco-2 models. In conclusion, BNC is suitable as an alternative bioscaffold of non-animal origin for the development of functional organ models in vitro.
Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies
Daniela Zdzieblo
Added on: 07-07-2022
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