Nowadays, biopolymers such as bacterial nanocellulose (BNC) represent interesting scaffold materials for innovative tissue engineering concepts, as they can be produced in a faster and standardized process flow without the need for animal material. In this study, BNC was presented as a suitable support for the development of Caco-2-based in vitro models of human intestine. The BNC-based models exhibited organ-specific properties that included typical cellular morphologies, characteristic protein expression profiles, representative ultrastructural features, and the formation of a dense epithelial barrier. The demonstration of in vivo-like transport activities confirmed the high quality of the BNC-based Caco-2 models. In conclusion, BNC is suitable as an alternative bioscaffold of non-animal origin for the development of functional organ models in vitro.
Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies
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