Non Animal Testing Database

Hypoxic 3D pancreatic cancer model

December 2021
University College London, London, United Kingdom
In this study, the impact of in vitro hypoxia (5% O2) on the radiotherapy treatment response of pancreatic cancer cells (PANC-1) was investigated in a novel polymer-based macroporous scaffold that was surface modified with proteins for extracellular matrix mimicry. The results demonstrated an increased post-radiation viability and reduced apoptosis, in hypoxia compared to normoxic cultures, revealing hypoxia-induced radioprotection. The novel platform for radiation treatment screening enables a more accurate preclinical assessment of treatment strategies.
On the evaluation of a novel hypoxic 3D pancreatic cancer model as a tool for radiotherapy treatment screening
Eirini Velliou
Added on: 06-22-2022
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