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A functional map of HIV-host interactions in primary human T cells

2022
Northwestern University Feinberg School of Medicine, Chicago, USA(1)
University of California, San Francisco, USA(2)
In the study, T cells, the major cell type targeted by HIV, were isolated from donated human blood and hundreds of genes were knocked out using CRISPR-Cas9 gene editing. The “knock-out” cells were then infected with HIV and analysed. The researchers found 86 genes that may play a role in the way HIV replicates and causes disease, including over 40 that have never been looked at in the context of HIV infection. The study highlights a new way of understanding how HIV integrates into our DNA and establishes a chronic infection, leading towards new treatments.
A functional map of HIV-host interactions in primary human T cells
Judd F. Hultquist(1), Nevan J. Krogan(2), Alexander Marson(2)
#1458
Added on: 06-09-2022
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