The presented study investigates the effect of maternal exposure to cadmium (Cd), an environmental toxin, using a four-chamber feto-maternal interface (FMi)-organ-on-a-chip. The chip incorporates maternal decidua cells and three different fetal cells of human origin. Cd transport through the FMi and its impact on the cell cycle, cell death, and inflammation were analyzed. Cd treatment resulted in significant cell death and a pro-inflammatory environment in the maternal decidua but had minimal effect on the fetal chorion cells, and no effect on the other fetal cells. The maternal response, but lack of fetal response, indicates that Cd-mediated adverse effects originate from maternal pathophysiology rather than fetal-derived triggers of preterm labour. This study demonstrates that the FMi- organ-on-a-chip can predict the response of FMi upon exposure to chemicals, opening the possibility for environmental toxin screens.
Molecular mechanisms of environmental toxin cadmium at the feto-maternal interface investigated using an organ-on-chip (FMi-OOC) model
The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.
Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!