Non Animal Testing Database

In silico simulation to distinguish components of pulmonary arterial hypertension

Maastricht University, Maastricht, Netherlands
Pulmonary arterial hypertension (PAH) is a disease characterized by a high mean pulmonary arterial pressure which impairs the correct function of the right ventricle (RV). Increased RV wall tension has been suggested to cause rapid leftward septal motion (RLSM) in the left ventricle. Progression of RV failure is associated with high mortality in patients with PAH. In the present study, the researchers aimed at using an in silico approach to more accurately assess RV function which could improve the diagnosis of RV failure. The researchers adapted the existing CircAdapt computational model to simulate myocardial tissue and pump function. Simulations of healthy circulation and mild, moderate, and severe PAH were performed. The researcher also assessed the co-existing effects of RV and RLSM. The model allows identifying how RV and RLSM evolve and influence each other through time and allow for a better understanding of disease progression.
Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model
Georgina Palau-Caballero
Added on: 12-03-2021
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