Non Animal Testing Database

In-silico assessment of the dynamic effects of drugs on human atrial patho-electrophysiology

November 2014
Institute of Technology (KIT), Karlsruhe, Germany
Atrial fibrillation (AF) is a relevant arrhythmia due to its high prevalence and association with severe complications. Atrial fibrillation is treated with various antiarrhythmic drugs, such as amiodarone and dronedarone. Besides certain differences in the inhibitory effects on ion channels, both drugs differ markedly in their pharmacokinetic properties. In the present study, the researchers aimed at investigating the complex effects of these drugs in an in-silico model of human atrial electrophysiology. The pharmacodynamics of amiodarone and dronedarone were investigated with respect to their dose and heart rate dependence by evaluating 10 descriptors of action potential morphology and conduction properties. An arrhythmia score was computed. The data gives possible explanations for the superior efficacy of amiodarone and may aid in the design of substrate-specific pharmacotherapy for AF.
In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology
Axel Loewe
Added on: 12-02-2021
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