Non Animal Testing Database

Antiadhesive resins biocompatible with human gingival fibroblasts

J.W. Goethe University, Frankfurt am Main, Germany
Secondary caries is linked to the failure of composite fillings and antibacterial treatments have been shown to modify biofilm formation. However, currently, there are available antiadhesive composites that diminish bacterial adhesion. Here, primary human gingival fibroblasts were used to test the biocompatibility of four antiadhesive and antibacterial fillings through a delivery system based on novel polymeric hollow beads. The results showed that antibacterial fillings disrupted fibroblast physiology, which was recovered with elution time. Moreover, one of the composites also had a negative effect on the cell membrane and, thus, on cell viability. Overall, the researchers demonstrate the negative effects that the antibacterial composites can have on human gingival fibroblasts and propose antiadhesive compounds as the most biocompatible to use in future applications.
The effect of new anti-adhesive and antibacterial dental resin filling materials on gingival fibroblasts
Philipp Landenberger
Added on: 12-01-2021
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