Non Animal Testing Database

In vitro inhalation testing

VITO NV, Mol, Belgium
To assess the toxicological potential or efficacy of inhalable substances for humans, the company VITO uses the so-called "air-liquid interface" exposure method (ALI). Here, lung cells are grown on a membrane, supplied with a cell culture medium at the bottom and exposed to airborne substances (e.g. drugs, vaccines, chemicals, nanoparticles) at the top. VITO has a range of ALI exposure modules and aerosol generation systems (for dry powders and liquids) as well as measurement equipment for characterisation. Several different lung cell systems (mono- and co-culture cell lines as well as lung cells from human donors) are used. In addition, various options for dose determination and endpoint measurement are available.

VITO [1]   URL
Added on: 11-17-2021
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