Non Animal Testing Database
EnglischDeutsch

Smad3 shows anti-tumor activity in breast cancer cells

2014
Northwestern University Feinberg School of Medicine, Chicago, USA
Cyclin D1/CDK4 activity is upregulated in 50% of breast cancers and is involved in the inhibition of Smad3. However, it is still unclear whether how CDK4 inhibition can modulate Smad3-dependent cell/colony growth and apoptosis in breast cancer cells. Here, human breast cancer cells overexpressing cyclin D1 were used to investigate if CDK4 inhibitor, doxorubicin, modified Smad3 or a combination therapy could impact cancerous activity in these cells. The results showed that the combination therapy or the overexpression of Smad3 resistance to CDK4 phosphorylation lead to a decrease in colony formation and an inhibition of various cancer cell-related features. Moreover, the overexpression of the mutated Smad3 combined with doxorubicin treatment caused the greatest increase in the expression of apoptotic-related proteins. Overall, the researchers suggest an important Smad3 tumor suppression activity that can be synergistically complemented with doxorubicin treatment in cyclin D1-overexpressing cancer cells and point to CDK4 as a potential novel target in cancer therapy.
CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin
Jacqueline S Jeruss
#1133
Added on: 11-01-2021
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!