α1-antitrypsin is highly expressed in several types of cancer but its role in triple-negative breast cancer remains unknown. Here, human tissue from triple-negative breast cancer patients and cancerous and non-cancerous human breast cell lines were used to study the influence of α1-antitrypsin in cell migration and invasion and its molecular mechanisms in triple-negative breast cancer cells. The results showed that α1-antitrypsin is overexpressed in triple-negative breast cancer samples and correlated with tumor progression. Moreover, the silencing of α1-antitrypsin in cancer cells inhibited cell growth and migration at the same time that upregulated E-cadherin and tissue inhibitor of metalloproteinases 2. On the contrary, it downregulated other factors positively related to cell invasion and metastasis. Finally, the signalling pathway related to metastasis that activates α1-antitrypsin was identified. Overall, the researchers demonstrate that α1-antitrypsin has high levels of expression in triple-negative breast cancer tissue and that it has a positive regulatory role in metastasis, making it a potential target for new therapeutic strategies in triple-negative breast cancer.
Silence of α1-antitrypsin inhibits migration and proliferation of triple negative breast cancer cells
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